there's definitely some I never get to - I procmail into about a dozen diff sub-inboxes (including razor and spamassassin's output of course) and just list them in my muttrc "mailboxes" by priority. Some days I never get out of the first one :/
Hah! I do the exact same thing! Personal mail first, then LJ comments, then the mailing lists I run, then the local mailing lists, then the interesting mailing lists, then the ones I read occasionally, then my spam box.